Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model마우스 모델에서 SARS-CoV-2 공격에 대한 보호 반응 유도에 대한 최적화된 서열과 SARS-CoV-2의 스파이크 단백질 야생형 DNA 서열의 비교Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acid Against Antiviral binding breath CD4 CD8+ cellular immune responses cellular immunity challenge clinical trial contributing to COVID-19 CTL demonstrated DNA DNA vaccine expression full-length spike protein hACE2 humoral humoral and cellular immunity IFN-γ immune immune responses immunogen in vitro induction mice Model mouse Neutralizing antibodies optimization optimizations pGX-9501 platform Protective Protective effects protective response RBD binding response robust SARS-CoV-2 sequence spike Spike protein subsequent T cell T cells the vaccine Transgenic mouse Type virus wild-type wild-type sequence. [DOI] 10.1080/21645515.2021.2016201 PMC 바로가기 [Article Type] Article
Non-coding RNA in SARS-CoV-2: Progress toward therapeutic significanceArticle Published on 2022-12-012022-11-15 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] Antiviral biological processe China complications death disease Evidence extreme feasible Giving globe immune reaction increase Infection mechanism Molecular biology ncRNA ncRNAs non-coding RNA noncoding RNA Pathogenesis pathogenic virus preventing infection Progress Research resulting RNA SARS-CoV-2 SARS-CoV2 Spread subsequent Symptoms therapeutic therapy Therapy. virus virus infection [DOI] 10.1016/j.ijbiomac.2022.09.105 PMC 바로가기
Nanozyme-strip for rapid and ultrasensitive nucleic acid detection of SARS-CoV-2Article Published on 2022-12-012022-11-15 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome amplification amplify catalytic clinical sample coronavirus coronavirus disease COVID-19 develop Diagnosis gold standard highlighting HPV-16 limit of detection Nanozyme strips nontoxic nucleic acid nucleic acid amplification Nucleic acid detection pandemic POCT point-of-care point-of-care testing polymerase REcombinase recombinase polymerase amplification reliability RPA RT-PCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2. subsequent TMB unique viral infections virus [DOI] 10.1016/j.bios.2022.114739 PMC 바로가기
The Protection of Naturally Acquired Antibodies Against Subsequent SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis후속 SARS-CoV-2 감염에 대한 자연 획득 항체의 보호: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-12-012022-09-12 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI Acquired Against analyses analysis antibody asymptomatic infection conducted COVID-19 COVID-19 case COVID-19 infection COVID-19 vaccination Efficacy eligible General population HCWs Health care worker incidence rate individual Infection Meta-analysis Naturally naturally acquired antibody naturally acquired immunity Newcastle-Ottawa Scale NOS Older outcome Population programming protection provided reduce Registration Reinfection reinfection. review risk SARS-CoV-2 SARS-COV-2 infection searched seropositive significant difference significantly specific antibody subsequent symptomatic was used [DOI] 10.1080/22221751.2022.2046446 PMC 바로가기 [Article Type] Meta-Analysis
Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2Article Published on 2022-12-012022-11-16 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] change changes in Characteristics circulating cleavage contribute contributing to demonstrated dependent on determinant endosomal entry endosomal entry pathway endosomal pathway Entry facilitate feature Fusogenicity H655Y identify increase investigated less Mutation omicron Omicron BA.1 and BA.2 Pathogenesis pathogenicity plasma membrane predominant Proteases recent reduce reduced retained SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 WT serine protease spike spike mutation Spike protein spike protein cleavage. subsequent the spike protein TMPRSS2 transmembrane serine protease Virological virus entry [DOI] 10.1080/22221751.2022.2117098 PMC 바로가기
Wastewater surveillance allows early detection of SARS-CoV-2 omicron in North Rhine-Westphalia, GermanyArticle Published on 2022-11-102022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis approach close monitoring collected COVID-19 COVID-19 surveillance demonstrated detection Detection workflow dominant variant Epidemiology evaluate fraction Germany identify Initially K417N Laboratory Local MONITOR mutant Mutation N501Y NGS North omicron Omicron, B.1.1.529 PCR primer public health purified Regulation required resulting RT-qPCR SARS-CoV-2 SARS-CoV-2 epidemiology SARS-CoV-2 monitoring SARS-CoV-2 RNA SARS-CoV-2 variant Sequencing state subsequent Support Surveillance Treatment variant variant of concern was performed wastewater Wastewater-based epidemiology (WBE). [DOI] 10.1016/j.scitotenv.2022.157375 PMC 바로가기
Modelling optimal vaccination strategies against COVID-19 in a context of Gamma variant predominance in BrazilArticle Published on 2022-11-022022-11-16 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, [키워드] accompanied age AZD1222 Brazil circulating variant Coverage COVID-19 death deaths dose driven by Effectiveness Epidemic estimates evaluate evaluated Evidence Gamma group groups Guidance health system immunization immunization strategy implementation increase in inefficient initial International interval Local modelling Older age outcome populations reached reducing required subsequent Support vaccination Vaccination strategy Vaccine vaccine availability Vaccines. variant variants of concern VoC [DOI] 10.1016/j.vaccine.2022.09.082 PMC 바로가기
The negative impact of COVID-19 pandemic on age-related macular degeneration patients treated with intravitreal bevacizumab injectionsArticle Published on 2022-11-012022-11-15 Journal: International ophthalmology [Category] 진단, [키워드] adherent Age-related macular degeneration AMD bevacizumab change Clinical outcome Compliance COVID-19 COVID-19 pandemic defined Follow-up implication individual injection Injections intravitreal intravitreal injection lockdown Loss Loss of follow-up. not significant outcome pandemic Patient patients patients treated proportion remained study period subsequent visual acuity worldwide pandemic worsened [DOI] 10.1007/s10792-022-02337-y PMC 바로가기
Antibody response after COVID-19 vaccination in intravenous immunoglobulin-treated immune neuropathiesArticle Published on 2022-11-012022-11-15 Journal: European journal of neurology [Category] SARS, 진단, [키워드] Administered administration age Alter analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG antibodies COVID-19 COVID-19 vaccination COVID-19 vaccine decrease dose enzyme-linked immunosorbent female healthy subjects IgA IgA titer IgG IgG titer IgM immune immunoassay Immunoglobulin impair indicate Interaction intravenous Intravenous immunoglobulin IVIG Microparticle mRNA vaccine observation Patient positive Prevalence reduce remained sera serological response serum serum titer significantly subsequent the antibody response therapeutic vaccination Vaccine vaccine dose vaccine interaction. [DOI] 10.1111/ene.15508 PMC 바로가기
Prevalence of acute olfactory dysfunction differs between variants of SARS-CoV-2-results from chemosensitive testing in wild type, VOC alpha (B.1.1.7) and VOC delta (B.1617.2)Article Published on 2022-11-012022-11-16 Journal: European archives of oto-rhino-laryngology : offic [Category] COVID19(2023년), SARS, 변종, [키워드] acute SARS-CoV-2 infection Alpha B.1.1.7 blinded COVID-19 dysfunction Hyposmia impairment Next-generation sequencing Olfaction olfactory olfactory dysfunction olfactory function Patient Prevalence Prospective Study quantitative real-time PCR SARS-CoV-2 significant difference Smell Smell. subsequent symptoms of COVID-19 variant variants virus virus variant VoC wild type [DOI] 10.1007/s00405-022-07431-6 PMC 바로가기